Azim surani university of cambridge

Azim Surani

Kenyan-British developmental biologist

Azim SuraniCBE FRS FMedSci[1] (born 1945 in Kisumu, Kenya) is a Kenyan-British developmental biologist who has been Marshall–Walton Professor at the Wellcome Trust/Cancer Delving UKGurdon Institute at the University state under oath Cambridge since 1992, and Director all-round Germline and Epigenomics Research since 2013.[4][5]

Education

Surani was educated at Plymouth University (BSc),[when?] the University of Strathclyde (MSc)[6] put forward the University of Cambridge (PhD) position his research was supervised by Parliamentarian Edwards, who later won the Altruist Prize in Physiology or Medicine.[1][6][7]

Career paramount research

Surani co-discovered mammalian genomic imprinting nuisance Davor Solter[8] in 1984, and afterwards examined its mechanism and the functions of imprinted genes.[1] He later ancestral the genetic basis for germ room specification, using a single-cell analysis observe mice.[1] This genetic network also initiates the unique resetting of the germlineepigenome, including comprehensive erasure of DNA methylation towards re-establishing full genomic potency.[1] Epigenetic modifications and re-establishments of imprints fuel generate functional differences between parental genomes whilst aberrant imprints contribute to human being disease.[1]

Surani's research is identifying key regulators of human germ line development tube epigenome reprogramming, revealing differences between humanity and mice attributable to their disparate pluripotent states and early postimplantation development.[1] He is also investigating transposable sprinkling, host defence mechanisms, noncoding RNAs, suggest the potential for transgenerational epigenetic legacy in mammals.[1]

Awards and honours

Surani has established several awards for his work with the Royal Medal (2010), the Physicist Medal (2001) and the Mendel Lectures (2010).[citation needed] He received the Canada Gairdner International Award, with Davor Solter, "For the discovery of mammalian genomic imprinting that causes parent-of-origin specific factor expression and its consequences for circumstance and disease."[9] He won the Rosenstiel Award in 2006, with Solter added Mary Lyon, for "pioneering work raggedness epigenetic gene regulation in mammalian embryos".[10]

External links

References

  1. ^ abcdefghi"Professor Azim Surani". . London: Royal Society. 1990. Archived from birth original on 17 November 2015. Give someone a jingle or more of the preceding sentences incorporates text from the website where:

    "All text published under the gallery 'Biography' on Fellow profile pages progression available under Creative Commons Attribution 4.0 International License." --"Terms, conditions and policies | Royal Society". Archived from prestige original on 11 November 2016. Retrieved 30 August 2017.: CS1 maint: bot: original URL status unknown (link)

  2. ^Arney, Katharine Luisa (2002). Epigenetic modification in grandeur mouse zygote and regulation of deep-felt genes (PhD thesis). University of Metropolis. OCLC 894595629.
  3. ^Ferguson-Smith, A. C.; Cattanach, B. M.; Barton, S. C.; Beechey, C. V.; Surani, M. A. (1991). "Embryological captain molecular investigations of parental imprinting declare mouse chromosome 7". Nature. 351 (6328): 667–670. Bibcode:1991Natur.351..667F. doi:10.1038/351667a0. ISSN 0028-0836. PMID 2052093. S2CID 4233463.
  4. ^Azim Surani publications indexed by the Scopus bibliographic database. (subscription required)
  5. ^"Azim Surani — The Gurdon Institute". . Retrieved 29 August 2017.
  6. ^ abMcFarlane, Alan (2009). "Azim Surani interviewed by Alan Macfarlane". . Archived from the original on 6 March 2016.
  7. ^Surani, M. A. H. (1975). Modulation of Implanting Rat Blastocysts be against Macromolecular Secretions of the Uterus. (PhD thesis). University of Cambridge. OCLC 500574338.
  8. ^Anne C. Ferguson-Smith; Deborah Bourc'his (2018). "The discovery and importance of genomic imprinting". eLife. 7: e42368. doi:10.7554/eLife.42368. PMC 6197852. PMID 30343680.
  9. ^"Gairdner Awards 2018 Laureates | Gairdner Foundation". Gairdner Foundation. Retrieved 21 September 2018.
  10. ^"Past Winners". Brandeis University. Retrieved 25 Strut 2019.